In recent years, China’s pharmaceutical industry has developed rapidly, and the research and development of related equipment has also been highly valued by the pharmaceutical equipment industry. The current environmental protection theme has been mentioned. The granulation equipment manufacturers must grasp the transformation of the equipment and the improvement of the wet process, so as not to be eliminated by the market.
Among them, the wet mixing granulator is a solid preparation pharmaceutical device which has developed rapidly in recent years, and the two steps of mixing and granulation are combined in the process, which saves time and meets GMP requirements. In the process of reducing cross-contamination and improving granulation efficiency, it is a quick and good way to save the province. It is popular among users and widely used in pharmaceutical, food, chemical and other industries. In the pharmaceutical industry, wet mixed granulators account for 70% of the current market for several solid formulation granulation equipment, according to relevant statistics. Due to the use of the wet mixing granulator and the tablet press, the sales volume of the wet mixing granulator throughout the year has a high market share. The pharmaceutical industry is steadily moving forward, and the requirements for wet processes are becoming higher and higher. The wet granulation technology naturally needs to keep pace with the times. Only a more efficient, environmentally safe and safe granulation method can be Market application. The current market is unpredictable, wet mixing granulators must seize the market development trend, while maintaining their own price, easy maintenance and other advantages, but also should continue to improve the deficiencies, improve technical strength, in order to make it better for pharmaceuticals field. It is understood that in foreign countries, wet mixing granulators have been widely adopted, and domestic start is relatively late.
According to the industry, some domestic users choose pharmaceutical equipment from non-professional manufacturers. When they are on-site debugging, they do not understand the preparation process, and they do not know how to use them. The results have repeatedly failed and they have suffered. For the development of solid preparations in China, to help users use the wet mixing equipment purchased, the industry has published some knowledge for your reference. The author has carried out the following sorting. Generally speaking, the particles prepared by wet mixing granulation have irregular shape, uniform particle size distribution, better structure than other conventional granulation processes, strong compressibility, good solubility and moderate moisture permeability. At different granulating speeds, the particle size of the particles is between 12 and 100 mesh. The distribution range can be selected from different granulation speeds and stirring paddle speeds. (When the granulation speed is slow, the particle size becomes larger and the rotation speed is gradually increased. Accelerate and gradually reduce the particle size; when the stirring paddle speed is slow, the particle size is small, the rotation speed is gradually increased and the particle size is gradually increased, and the two functions play just the opposite). Conventional wet mixing granulators can be used to manually adjust the rotational speed of the agitating paddles and the granulation paddles in order to find experimental process parameters. That is to say, the two blade speeds are changed through different time, and the better particle size parameters are obtained. According to the two inverters, the program control is performed to ensure the quality and uniformity of batch and batch production.
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